Quantitating Cell–Cell Interaction Functions with Applications to Glioblastoma Multiforme Cancer Cells
نویسندگان
چکیده
منابع مشابه
Quantitating cell-cell interaction functions with applications to glioblastoma multiforme cancer cells.
We report on a method for quantitating the distance dependence of cell-cell interactions. We employ a microchip design that permits a multiplex, quantitative protein assay from statistical numbers of cell pairs, as a function of cell separation, with a 0.15 nL volume microchamber. We interrogate interactions between pairs of model brain cancer cells by assaying for six functional proteins assoc...
متن کاملSupporting Information Quantitating Cell-Cell Interaction Functions, with Applications to Glioblastoma Multiforme Cancer Cells
Jun Wang, Douglas Tham, Wei Wei, Young Shik Shin, Chao Ma, Habib Ahmad, Qihui Shi, Jenkan Yu, Raphael D. Levine, and James R. Heath NanoSystems Biology Cancer Center, Division of Chemistry and Chemical Engineering, Caltech, Pasadena CA 91125. The Fritz Haber Research Center for Molecular Dynamics, The Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. Crump Ins...
متن کاملO27: Interaction of Cancer Stem Cells and Microglia in Glioblastoma Multiforme
Malignant gliomas are highly invasive brain tumors with the occurrence of multiple microglia/macrophages in the tumor microenvironment. Macrophages/microglia that found in glioma microenvironment, as tumor-infiltrating immune cells, can play a harmful role in tumor progression. In addition, glioblastoma multiforme (GBM) contains multiple aberrant differentiation and tumorigenic cancer stem cell...
متن کاملCancer Stem Cells in Glioblastoma Multiforme
AIM To identify and characterize cancer stem cells (CSC) in glioblastoma multiforme (GBM). METHODS Four-micrometer thick formalin-fixed paraffin-embedded GBM samples from six patients underwent 3,3-diaminobenzidine (DAB) and immunofluorescent (IF) immunohistochemical (IHC) staining for the embryonic stem cell (ESC) markers NANOG, OCT4, SALL4, SOX2, and pSTAT3. IF IHC staining was performed to...
متن کاملGlioblastoma Multiforme Stem Cells
Glioblastoma multiforme (GBM) is an aggressive, malignant, and lethal brain tumor, resistant to all current forms of treatment. The rapidly emerging focus on cancer stem cells embodies a paradigm shift in our understanding of tumor pathogenesis, while the development of powerful genome-wide screening techniques has provided cause for optimism related to the development of more reliable therapie...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nano Letters
سال: 2012
ISSN: 1530-6984,1530-6992
DOI: 10.1021/nl302748q